Abstract
Among the plethora of heterocyclic nucleus discovered, the oxadiazoles have also been explored extensively. The oxadiazole structure has been demonstrated to bear important biological activities such as anti-cancer, antiinflammatory, anti-tuberculosis, anti-malarial and anti-schistosomiasis etc. The presence of oxadiazole motifs in diverse types of compounds proves its importance in the field of medicinal chemistry. This review is complementary to earlier reviews and covers recent updates of various pharmacological aspects of oxadiazoles. To help the reader better know the context for these approaches, a summary of various aspects of background of related topic is presented.
Keywords: Biological activities, Five membered heterocyclic ring, Oxadiazole.
Mini-Reviews in Medicinal Chemistry
Title:Recent Updates on Biological Activities of Oxadiazoles
Volume: 13 Issue: 7
Author(s): Rikta Saha, Omprakash Tanwar, Akranth Marella, M. Mumtaz Alam and Mymoona Akhter
Affiliation:
Keywords: Biological activities, Five membered heterocyclic ring, Oxadiazole.
Abstract: Among the plethora of heterocyclic nucleus discovered, the oxadiazoles have also been explored extensively. The oxadiazole structure has been demonstrated to bear important biological activities such as anti-cancer, antiinflammatory, anti-tuberculosis, anti-malarial and anti-schistosomiasis etc. The presence of oxadiazole motifs in diverse types of compounds proves its importance in the field of medicinal chemistry. This review is complementary to earlier reviews and covers recent updates of various pharmacological aspects of oxadiazoles. To help the reader better know the context for these approaches, a summary of various aspects of background of related topic is presented.
Export Options
About this article
Cite this article as:
Saha Rikta, Tanwar Omprakash, Marella Akranth, Mumtaz Alam M. and Akhter Mymoona, Recent Updates on Biological Activities of Oxadiazoles, Mini-Reviews in Medicinal Chemistry 2013; 13 (7) . https://dx.doi.org/10.2174/1389557511313070007
DOI https://dx.doi.org/10.2174/1389557511313070007 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Use of Affinity Tags to Overcome Obstacles in Recombinant Protein Expression and Purification
Protein & Peptide Letters Methicillin-Sensitive <i>Staphylococcus aureus</i> Pyogenic Iliopsoas Abscesses: A Case Series from Jodhpur, India
Infectious Disorders - Drug Targets MIANN Models in Medicinal, Physical and Organic Chemistry
Current Topics in Medicinal Chemistry Thalidomide Analogues as Anticancer Drugs
Recent Patents on Anti-Cancer Drug Discovery Synthesis of 2-, 3- or 4-phenylsubtituted Chalcones Based on 4- phenylamino-6-nitro-2-[(E)-2-phenylvinyl]quinoline, Evaluation of their Antimicrobial and Antifungal Activity
Letters in Drug Design & Discovery Integration of Biological Data with Semantic Networks
Current Bioinformatics Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens
Current Proteomics Hybolites: Novel Therapeutic Tools for Targeting Hyperstructures in Bacteria
Recent Patents on Anti-Infective Drug Discovery Vitamin D and Infectious Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Current Treatment and Drug Discovery Against Leishmania spp. and Plasmodium spp.: A Review
Current Drug Targets Immune Modulation by Regulatory T Cells in Helicobacter pylori-Associated Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets A Facile and Efficient One-pot Three Component Route to New Bis(1,2,4- Oxadiazole) Linked with Polyoxyethylene Chain
Letters in Organic Chemistry Synthesis of Some Novel 4-(Arylideneamino)-N'-((2-chloro-8-methylquinolin- 3-yl)methylene)-3-phenyl-2-thioxo-2,3-dihydrothiazole-5-carbohydrazides as Potential Antimicrobial Agents
Letters in Drug Design & Discovery Short-Term Transfer of Knowledge Assessment in the Military International HIV Training Program (MIHTP)
Current HIV Research In Vitro Anti-mycobacterial Activity of Three Medicinal Plants of Lamiaceae Family
Recent Patents on Anti-Infective Drug Discovery Molecules of Infectious Agents as Immunomodulatory Drugs
Current Topics in Medicinal Chemistry Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Medical and Societal Impact
Current Immunology Reviews (Discontinued) The Multifaceted Roles of Molecular Dynamics Simulations in Drug Discovery
Current Pharmaceutical Design Synthesis, Anti-cancer Activity and Mechanism Study of 6-Mercapto-purine Derivatives
Letters in Drug Design & Discovery Radiolabeled Iron Oxide Nanoparticles As Dual-Modality SPECT/MRI and PET/MRI Agents
Current Topics in Medicinal Chemistry