Computational Methods in Determination of Pharmacophore Models of 5-HT1A, 5-HT2A and 5-HT7 Receptors

Author(s): Anna Bielenica, Anna E. Koziol, Marta Struga.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 7 , 2013

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Abstract:

The present paper discusses models of 5-HT1A and 5-HT2A receptors, developed by conformational analysis and 3D-QSAR methods. Hypotheses concerning the ligand-5-HT7 receptor interaction were complemented by models constructed on the basis of the receptor's structure. Various pharmacophore concepts are supported by structures of exemplary ligands and groups of compounds, derived from chain polycyclic arylpiperazines, used for models generations.

Keywords: arylpiperazine, pharmacophore model, 5-HT1A receptor, 5-HT2A receptor, 5-HT7 receptor.

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Article Details

VOLUME: 13
ISSUE: 7
Year: 2013
Page: [933 - 951]
Pages: 19
DOI: 10.2174/1389557511313070001
Price: $58

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