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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Invertebrate FMRFamide Related Peptides

Author(s): Kevin G. Krajniak

Volume 20, Issue 6, 2013

Page: [647 - 670] Pages: 24

DOI: 10.2174/0929866511320060005

Abstract

In 1977 the neuropeptide FMRFamide was isolated from the clam, Macrocallista nimbosa. Since then several hundred FMRFamide-related peptides (FaRPs) have been isolated from invertebrate animals. Precursors to the FaRPs likely arose in the cnidarians. With the transition to a bilateral body plan FaRPs became a fixture in the invertebrate phyla. They have come to play a critical role as neurotransmitters, neuromodulators, and neurohormones. FaRPs regulate a variety of body functions including, feeding, digestion, circulation, reproduction, movement. The evolution of the molecular form and function of these omnipresent peptides will be considered.

Keywords: FMRFamide, FaRPs, cnidaria, platyhelminthes, nematoda, annelida, mollusca, arthropoda.


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