Invertebrate FMRFamide Related Peptides

Author(s): Kevin G. Krajniak.

Journal Name: Protein & Peptide Letters

Volume 20 , Issue 6 , 2013

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Abstract:

In 1977 the neuropeptide FMRFamide was isolated from the clam, Macrocallista nimbosa. Since then several hundred FMRFamide-related peptides (FaRPs) have been isolated from invertebrate animals. Precursors to the FaRPs likely arose in the cnidarians. With the transition to a bilateral body plan FaRPs became a fixture in the invertebrate phyla. They have come to play a critical role as neurotransmitters, neuromodulators, and neurohormones. FaRPs regulate a variety of body functions including, feeding, digestion, circulation, reproduction, movement. The evolution of the molecular form and function of these omnipresent peptides will be considered.

Keywords: FMRFamide, FaRPs, cnidaria, platyhelminthes, nematoda, annelida, mollusca, arthropoda.

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Article Details

VOLUME: 20
ISSUE: 6
Year: 2013
Page: [647 - 670]
Pages: 24
DOI: 10.2174/0929866511320060005

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