Translational Application of In Vivo Imaging and Analysis of Atherosclerotic Plaque Vulnerability Assessment
Kiyoko Uno, Yu Kataoka, Rishi Puri and Stephen J. Nicholls
Affiliation: South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, SA, 5001, Australia.
Keywords: Anatomical imaging, arterial wall imaging, cardiovascular event, intravascular ultrasound, molecular targeted
imaging, vulnerable plaque.
Whereas atheroma progression/regression studies have focused on luminal narrowing or atheroma burden, the
current notion that inflammation and immune response may contribute to the development of plaque rupture has garnered
increased interest. As the disease process has become increasingly defined, this provides a range of potential targets to be
employed by emerging imaging techniques. With ongoing developments in vascular imaging to visualize compositional
and biological features in atherosclerotic plaque, there is considerable interest in the incremental information that can be
ascertained. A selective overview of emerging modalities and patents to image the artery wall and the potential target is
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