Abstract
The evolution of orthologous proteins opens a new era of research where the concepts of orthology and paralogy have become more and more substantial, as the whole-genome comparison allows their identification in complete genomes. Functional specificity of proteins is understood to be conserved among orthologs but it shows much more variability among paralogs. We used this laying claim to identify inter-species interactions based on orthologous protein networks which are crucial for understanding the evolution of orthologous proteins. We analyzed six classes of enzymatic protein sequence data using the node degrees of orthologous proteins. The results demonstrated the evolutionary importance of the fatty acid syntheses and the photosynthetic system in algae. Methods which have successfully exploited network structure at many different levels of detail are a cornerstone of systems biology.
Keywords: Orthology, Network degree, Enzyme, System biology.
Current Topics in Medicinal Chemistry
Title:Metabolism Evolution Based on Network Degrees of Orthologous Enzymes
Volume: 13 Issue: 5
Author(s): Kirtan Dave and Hetalkumar Panchal
Affiliation:
Keywords: Orthology, Network degree, Enzyme, System biology.
Abstract: The evolution of orthologous proteins opens a new era of research where the concepts of orthology and paralogy have become more and more substantial, as the whole-genome comparison allows their identification in complete genomes. Functional specificity of proteins is understood to be conserved among orthologs but it shows much more variability among paralogs. We used this laying claim to identify inter-species interactions based on orthologous protein networks which are crucial for understanding the evolution of orthologous proteins. We analyzed six classes of enzymatic protein sequence data using the node degrees of orthologous proteins. The results demonstrated the evolutionary importance of the fatty acid syntheses and the photosynthetic system in algae. Methods which have successfully exploited network structure at many different levels of detail are a cornerstone of systems biology.
Export Options
About this article
Cite this article as:
Dave Kirtan and Panchal Hetalkumar, Metabolism Evolution Based on Network Degrees of Orthologous Enzymes, Current Topics in Medicinal Chemistry 2013; 13 (5) . https://dx.doi.org/10.2174/1568026611313050009
DOI https://dx.doi.org/10.2174/1568026611313050009 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nanomedicine and its Potential for the Treatment of Alzheimer’s Disease
Current Nanomedicine Truncated Human Cathepsin L, Encoded by a Novel Splice Variant, Exhibits Altered Subcellular Localization and Cytotoxicity
Protein & Peptide Letters MicroRNA: Biogenesis, Function and Role in Cancer
Current Genomics Sol-Gel Chemistry in Biosensing Devices of Electrical Transduction: Application to CEA Cancer Biomarker
Current Topics in Medicinal Chemistry Coenzyme Q10 Reduction with Statins: Another Pleiotropic Effect
Current Drug Therapy Novel Anti-Angiogenic Compounds for Application in Tumor Therapy – COP9 Signalosome-Associated Kinases as Possible Targets
Mini-Reviews in Medicinal Chemistry CD95 Signaling in Cancer Treatment
Current Pharmaceutical Design Pharmacogenomics in Colorectal Cancer
Current Pharmacogenomics Advances in Nano Drugs for Cancer Chemotherapy
Current Cancer Drug Targets TGF-β2 Signaling in High-Grade Gliomas
Current Pharmaceutical Biotechnology Small Molecules Targeting Ataxia Telangiectasia and Rad3-Related (ATR) Kinase: An Emerging way to Enhance Existing Cancer Therapy
Current Cancer Drug Targets Neuroblastoma and Stem Cell Therapy: An Updated Review
CNS & Neurological Disorders - Drug Targets Synergistic Antiproliferative and Antiangiogenic Effects of EGFR and mTOR Inhibitors
Current Pharmaceutical Design Butyrate and Colorectal Cancer: The Role of Butyrate Transport
Current Drug Metabolism Curcumin: A Promising Agent Targeting Cancer Stem Cells
Anti-Cancer Agents in Medicinal Chemistry Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling
Current Medicinal Chemistry Natural Products as Anticancer Agents
Current Drug Targets Effects of Physical Exercise on Inflammatory Markers of Atherosclerosis
Current Pharmaceutical Design Damage and Recovery of the Bone Marrow Microenvironment Induced by Cancer Chemotherapy – Potential Regulatory Role of Chemokine CXCL12/Receptor CXCR4 Signalling
Current Molecular Medicine Nanoemulsions for Improved Efficacy of Phytotherapeutics- A Patent Perspective
Recent Patents on Nanotechnology