Synthesis of Benzophenonehydrazone Schiff Bases and their In Vitro Antiglycating Activities

Author(s): Khalid Mohammed Khan, Fazal Rahim, Nida Ambreen, Muhammad Taha, Momin Khan, Humaira Jahan, Najeebullah, Azizuddin Shaikh, Sarosh Iqbal, Shahnaz Perveen, Muhammad Iqbal Choudhary.

Journal Name: Medicinal Chemistry

Volume 9 , Issue 4 , 2013

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Abstract:

Benzophenonehydrazone Schiff bases 1-25 were synthesized and their in vitro antiglycation potential has been studied. Out of twenty-five compounds, thirteen showed varying degrees of antiglycation activity with IC50 values ranging between 25.7 - 305 μM, if compared with the standard rutin (IC50 = 70.5 ± 0.50 μM). Compounds 21 (2,3- dihydroxybenzaldehyde N-(diphenylmethylene)hydrazine) IC50 = 25.7 ± 0.003 μM, 14 (diphenylmethanone N-[1-(2,4- dihydroxy-5-nitrophenyl)ethylidene]hydrazine) IC50 = 36.6 ± 0.004 μM, 6 (3,4-dihydroxybenzaldehyde N- (diphenylmethylene)hydrazine) IC50 = 49.5 ± 0.001 μM, 13 (diphenylmethanone N-[1-(2,5-dihydroxyphenyl)ethylidene] hydrazine) IC50 = 52.6 ± 0.023 μM, and 15 (diphenylmethanone N-[1-(3,4-dihydroxyphenyl)ethylidene]hydrazine) IC50 = 57 ± 0.002 μM, showed showed much better antiglycation potential superior to the standard rutin. The compounds 7 (2,5- dihydroxybenzaldehyde N-(diphenylmethylene)hydrazine) IC50 = 66 ± 0.002 μM, and 25 (diphenylmethanone N-[1-(2,5- dihydroxyphenyl)propylidene] hydrazine) IC50 = 67.9 ± 0.001 μM showed compareably good antiglycation activity to standard rutin. All compounds were characterized by spectroscopic techniques and gave satisfactory elemental analysis.

Keywords: Benzophenonehydrazone, Schiff bases, antiglycation, AGEPs

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2013
Page: [588 - 595]
Pages: 8
DOI: 10.2174/1573406411309040013
Price: $58

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