The Synthesis, Structural Study and Anticancer Activity Evaluation of Emodin Derivatives Containing Conjugative Groups

Author(s): Wang Wen-Feng, Zhang Feng-Sen, Zhao Wen-Na, Bai Ze-Dong, Yang Hui-Jun, Shao Jing-Wei, Yuan Yao-Feng.

Journal Name: Medicinal Chemistry

Volume 9 , Issue 4 , 2013

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Abstract:

Eight new emodin derivatives that contain large conjugative system have been synthesized and their anticancer activities also have been evaluated. The result shows that large conjugative system can not enhance the anticancer activities of emodin derivatives, but the introduction of an alkylating center can make emodin derivative effective against cancer cell lines. Compound 12 has the highest alkylating ability, but its anticancer activity is not remarkable, which indicates that there is not a direct correlation between the chemical reactivity of the alkylating agent and the toxic effects.

Keywords: Emodin derivatives, anticancer activity, synthesis, conjugative groups

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2013
Page: [545 - 552]
Pages: 8
DOI: 10.2174/1573406411309040008
Price: $58

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