Eight new emodin derivatives that contain large conjugative system have been synthesized and their anticancer
activities also have been evaluated. The result shows that large conjugative system can not enhance the anticancer activities
of emodin derivatives, but the introduction of an alkylating center can make emodin derivative effective against cancer
cell lines. Compound 12 has the highest alkylating ability, but its anticancer activity is not remarkable, which indicates
that there is not a direct correlation between the chemical reactivity of the alkylating agent and the toxic effects.
Keywords: Emodin derivatives, anticancer activity, synthesis, conjugative groups
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