Targeting Mitochondria for Cardiac Protection

Author(s): Sauri Hernandez-Resendiz, Mabel Buelna-Chontal, Francisco Correa, Cecilia Zazueta.

Journal Name: Current Drug Targets

Volume 14 , Issue 5 , 2013

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Abstract:

The critical role of mitochondria in cardiomyocyte survival and death has become an exciting field of research in cardiac biology. Indeed, it is accepted that mitochondrial dysfunction plays a crucial role in the pathogenesis of multiple cardiac diseases. Besides the obvious relevance of mitochondria in energy production, calcium homeostasis, and reactive oxygen species (ROS) production, new processes like mitochondrial fusion/fission, phosphorylation and nitrosylation modifications in mitochondrial proteins have been suggested to form part of a cast of key players in cardiac disease. This review describes currently studied drugs and compounds that target mitochondria in the scenario of cardiovascular diseases.

Keywords: Apoptosis, cardioprotection, fusion and fission processes, mitochondrial biogenesis, mitochondrial calcium transport, oxidative stress.

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Article Details

VOLUME: 14
ISSUE: 5
Year: 2013
Page: [586 - 600]
Pages: 15
DOI: 10.2174/1389450111314050008
Price: $58

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