The critical role of mitochondria in cardiomyocyte survival and death has become an exciting field of research
in cardiac biology. Indeed, it is accepted that mitochondrial dysfunction plays a crucial role in the pathogenesis of multiple
cardiac diseases. Besides the obvious relevance of mitochondria in energy production, calcium homeostasis, and reactive
oxygen species (ROS) production, new processes like mitochondrial fusion/fission, phosphorylation and nitrosylation
modifications in mitochondrial proteins have been suggested to form part of a cast of key players in cardiac disease. This
review describes currently studied drugs and compounds that target mitochondria in the scenario of cardiovascular diseases.
Keywords: Apoptosis, cardioprotection, fusion and fission processes, mitochondrial biogenesis, mitochondrial calcium transport,
Rights & PermissionsPrintExport