3,4,5-substituted furan-2(5H)-ones were One-Pot Multi-Component synthesized by the reaction of aldehydes,
amines and dialkyl acetylenedicarboxylates using silica gel-supported polyphosphoric acid (PPA/SiO2) at room temperature.
This reaction provides a convenient and efficient synthetic method of furan-2(5H)-one derivatives, and also reusability
Keywords: PPA/SiO2, 3, 4, 5-substituted furan-2(5H)-ones, aldehydes, amines, dialkyl acetylenedicarboxylates
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