Ionic Liquid Mediated Synthesis of Novel tetrahydroimidazo [1,2- a]pyrimidine-6-carboxylate Derivatives

Author(s): Vinod V. Thorat, Satish A. Dake, Satish U. Deshmukh, Elayaraja Rasokkiyam, Mohd. Farees Uddin, Rajendra P. Pawar.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 3 , 2013

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Abstract:

A novel route for the synthesis of tetrahydroimidazo [1,2-a] pyrimidine-6-carboxylate derivatives in presence of 1-ethyl-3-methyl imidazolium hydrogen sulphate ionic liquid at room temperature has been reported via Biginelli reaction. The process offer several advantages such as short reaction time, excellent yield of products, simple work up procedure etc. 1-ethyl-3-methyl imidazolium hydrogen sulphate ionic liquid is utilized as solvent system and catalyst to enhance the rate of reactions.

Keywords: Aromatic aldehydes, Biginelli reaction, Catalyst, Ionic liquid, 5-amino-4, 5-dihydro-1H-pyrazole-4-carbonitrile

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2013
Page: [178 - 184]
Pages: 7
DOI: 10.2174/1570178611310030006
Price: $58

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