La(NO3)3.6H2O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines

Author(s): Mir Rasul Mousavi, Jasem Aboonajmi, Malek Taher Maghsoodlou, Nourallah Hazeri, Sayyed Mostafa Habibi-Khorassani, Mohyeddin Safarzaei.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 3 , 2013

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Abstract:

La(NO3)3.6H2O was used as an efficient catalyst for highly diastereoselective synthesis of functionalized piperidines by one-pot five-component reactions of anilines and aromatic aldehydes with acetoacetic esters. This strategy proceeds by way of the Knoevenagel reaction followed by inter-molecular aza-Diels-Alder reaction. The main features of the current method comprise mild reaction conditions, easy work-up, eco-friendliness, high atom economy, short times and the products were isolated with high yields.

Keywords: Lanthanum nitrate hexahydrate, piperidine, one-pot, multicomponent

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2013
Page: [171 - 177]
Pages: 7
DOI: 10.2174/1570178611310030005
Price: $58

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