The synthesis of enantiomers of 6-tert-butyl-6-methylmorpholine-2,5-dione (3) using Wang resin supported 2-
chloro- or 2-bromo- pyridinium triflate is described. The applied methodology could be considered as an interesting alternative
to “classical” one and enables the synthesis of 6-tert-butyl-6-methylmorpholine-2,5-dione with higher yields and
the isolation of product (3) is significantly easier.
Keywords: Wang resin supported Mukaiyama reagent, enantiomers of 6-tert-butyl-6-methylmorpholine-2, 5-dione, glycine
Rights & PermissionsPrintExport