Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents

Author(s): Mehlika Dilek Altintop, Ahmet Ozdemir, Zafer Asim Kaplancikli, Gulhan Turan-Zitouni, Gokalp Iscan, Gulsen Akalin Ciftci.

Abstract:

In this study, N-(benzothiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives (1-24) were obtained by the reaction of 2-chloro-N-(benzothiazole-2-yl)acetamides with piperidine derivatives. The structures of the compounds were elucidated by 1H-NMR and mass spectral data and elemental analysis. The compounds were screened for their antimicrobial activities against pathogenic bacteria and Candida species. The compounds were also investigated for their cytotoxic properties using MTT assay. The microbiological results revealed that the compounds were more effective against fungi than bacteria. Among Candida species, C. utilis was the most susceptible fungus to compounds 7 and 11. It is apparent that 2,6-dimethylpiperidine group and chloro and methyl substituents on benzothiazole ring have an important impact on anticandidal activity. MTT assay indicated that the effective doses of these derivatives were lower than their cytotoxic doses.

Keywords: Amide, Benzothiazole, Piperidine, Antimicrobial activity, Cytotoxicity

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2013
Page: [453 - 461]
Pages: 9
DOI: 10.2174/1570180811310050013
Price: $58