Perchloric acid adsorbed on magnetic Fe3O4 nano-particles coated with silica (Fe3O4@SiO2-HClO4) as a magnetically separable
nano-catalyst was prepared and used for the preparation of 1,4-dihydropyridine derivatives via multi-component reaction of cinnamaldehyde,
aromatic amines and methyl / ethyl acetoacetate in high yields. Quantitative conversion of the reactants was achieved under
solvent-free conditions; recycle of the catalyst, through convenient magnetic decantation, shows non-significant loss in activity. The
prepared nano-composite has been subjected for thorough characterization with X-ray diffraction (XRD) and Field Emission Scanning
Electron Microscope (FE-SEM) techniques. The average particle size of nano-particles was obtained as 70 nm.
Keywords: Fe3O4 nano-particles, Fe3O4@SiO2-HClO4, 1, 4-dihydropyridine, Hantzsch reaction, magnetically separable nano-catalyst, cinnamaldehyde.
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