Click-Chemistry in Biocatalysis

Author(s): Jose M. Palomo.

Journal Name: Current Organic Chemistry

Volume 17 , Issue 7 , 2013

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Abstract:

The application of specific chemical strategies to alter the structure of enzymes in order to improve their catalytic properties in different biotransformations has been a central role in biocatalysis in recent years. Particularly, cycloaddition reactions have represented a successfully methodology for enzyme chemistry because it is chemoselective and extremely rate-accelerated in aqueous media. Some of the most current examples in the use of click chemistry for site-specific modification and immobilization of enzymes has been reviewed in the present article.

Keywords: 1, 3-dipolar cycloaddition, Diels-Alder reaction, chemical modification, biocatalysis, biotransformations, selectivity, chemoselectivity, enatioselectivity.

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Article Details

VOLUME: 17
ISSUE: 7
Year: 2013
Page: [691 - 700]
Pages: 10
DOI: 10.2174/1385272811317070005

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