Catalytic Asymmetric Synthesis of γ-Butenolides by Direct Vinylogous Reactions

Author(s): Lin Yan, Xiaohong Wu, Hongjun Liu, Liangying Xie, Zhiyong Jiang.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 6 , 2013

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The γ-butenolide structural motif is a prominent feature in many bioactive natural products and drugs. This short review summarizes catalytic asymmetric synthesis of γ-butenolides through direct vinylogous reactions by metal complexes and organocatalysts. In light of building chiral γ-tertiary and quaternary carbon centers of butenolides, three synthetic strategies are included: 1) the reactions with furanone derivatives as nucleophiles, 2) olefination of γ,γ- disubstituted butenolides and 3) the reactions by using γ,γ-disubstituted butenolides as nucleophiles.

Keywords: Asymmetric synthesis, Vinylogous, Butenolides

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Article Details

Year: 2013
Page: [845 - 853]
Pages: 9
DOI: 10.2174/1389557511313060007
Price: $58

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