Nucleophilic phosphine catalysis has proven to be a practical and powerful synthetic strategy in organic
chemistry, which can provide easy access to five-, six-, seven-, and eight-membered nitrogen heterocyclic compounds.
The reaction topologies can be controlled by a proper choice of the phosphine catalysts, as well as the functionalization of
the reaction substrates. In many cases, the reactions take place smoothly at room temperature, with high efficiency and
atom economy. This mini-review presents the recent advances in nucleophilic phosphine catalysis for the synthesis of
drug-like nitrogen heterocylic compounds. The nitrogen heterocyclic compounds with significant biological activities
derived from the library based on nucleophilic phosphine-catalyzed annulation reactions are also highlighted.
Keywords: Phosphine organocatalysis, nitrogen heterocyclic compounds, dihydropyrrole, tetrahydropyridine
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