Transition Metal-Catalyzed Efficient and Green Transformations of P(O)-H Compounds to Functional Organophosphorus Compounds

Author(s): Qing Xu , Yong-Bo Zhou , Chang-Qiu Zhao , Shuang-Feng Yin , Li-Biao Han .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 6 , 2013

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Abstract:

Organophosphorus compounds are of high importance in organic synthesis, catalysis, biochemistry, pharmaceuticals, and material science. In this mini review, we summarize our recent studies on transition metal-catalyzed green and atom efficient transformations of P(O)-H bonds to various versatile organophosphorus compounds, including the highly regio- and stereoselective P(O)-H additions to carbon-carbon unsaturated compounds, asymmetric hydrophosphorylation reactions, and dehydrogenative coupling reactions of P(O)-H compounds with carbon-H and heteroatom-H compounds. These new reactions provide efficient, general and practical ways for the preparation of a variety of well-defined functional organophosphorus compounds. Mechanistic aspects related to the catalytic processes are also discussed.

Keywords: Transition metal catalyst, P(O)-H compound, carbon-carbon unsaturated compound, regio- and stereoselective addition, carbon-H and heteroatom-H compounds, dehydrogenative coupling reactions, well-defined functional organophosphorus compound

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2013
Page: [824 - 835]
Pages: 12
DOI: 10.2174/1389557511313060005
Price: $58

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