Engineering Approaches to Develop the Next Generation of Antibodies to Respiratory Targets

Author(s): Katherine A. Vousden, Deborah L. Clarke, David C. Lowe.

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)

Volume 12 , Issue 2 , 2013

Submit Manuscript
Submit Proposal

Abstract:

Chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) represent a significant health burden worldwide and are a major unmet medical need. Asthma affects over 300 million people and leads to 250,000 deaths per year, with an increasing prevalence particularly in developing countries. Although a large proportion of asthmatics are maintained on beta agonists and corticosteroids, there still remains a group of patients where these medicines fail to modulate symptoms and who may therefore benefit from monoclonal antibody based drugs that are aimed at controlling the disease. COPD is a cigarette smoke-driven chronic inflammatory airway disease with an increasing global prevalence. Given that current therapies fail to prevent disease progression or mortality, this patient population is also a focus for the development of monoclonal antibody therapies.

At present anti-IgE (omalizumab, Xolair®) is the only monoclonal antibody based drug approved in the respiratory space for the treatment of asthma. However, an increasing number of antibodies targeting key mediators/pathways of disease are in clinical development for both asthma and COPD, including targeting the Th2 pathway for asthma (anti-IL-4/5/13) and the pro-inflammatory cytokine IL-1 for COPD. This review will examine the antibody engineering approaches used to develop the next generation of antibodies, with a focus on respiratory disease.

Keywords: Antibody, asthma, COPD.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 12
ISSUE: 2
Year: 2013
Page: [99 - 108]
Pages: 10
DOI: 10.2174/1871528111312020004
Price: $58

Article Metrics

PDF: 11