Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial Synthesis

Author(s): Amit Verma, Mange Ram Yadav, Rajani Giridhar, Navnit Prajapati, Avinash C. Tripathi, Shailendra K. Saraf.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 16 , Issue 5 , 2013

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Abstract:

The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.

Keywords: Benzodiazepine, combinatorial synthesis, cyclic peptides, nitrogen heterocyclics, privileged structures, purines and pyrimidines, solid-phase synthesis.

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Article Details

VOLUME: 16
ISSUE: 5
Year: 2013
Page: [345 - 393]
Pages: 49
DOI: 10.2174/1386207311316050003
Price: $58

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