Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after
embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members,
regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial
development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis
of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to
the two closely related pathological systems: inflammation and cancer.