Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents

Title:Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents

Volume: 10 Issue: 2

Author(s): Saida Benzerka, Abdelmalek Bouraiou, Sofiane Bouacida, Thierry Roisnel, Chafia Bentchouala, Farida Smati, Bertrand Carboni and Ali Belfaitah

Affiliation:

Keywords: 2-Phenylquinoline, heterocycles, crystal structure, antimicrobial activity, minimum inhibitory concentration

Abstract: Some new unfused tricyclic aromatic systems containing various heterocyclic cores were synthesized. These compounds were prepared in good yields via appropriate routes using 6-methyl-2-phenylquinoline-3-carbaldehyde as a key intermediate. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Salmonella thipymurium using the disk-diffusion method. The minimum inhibitory concentration (MIC) was determined for the tested compounds.

Cite this article as:

Benzerka Saida, Bouraiou Abdelmalek, Bouacida Sofiane, Roisnel Thierry, Bentchouala Chafia, Smati Farida, Carboni Bertrand and Belfaitah Ali, Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents, Letters in Organic Chemistry 2013; 10 (2) . https://dx.doi.org/10.2174/1570178611310020005