Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents

Author(s): Saida Benzerka, Abdelmalek Bouraiou, Sofiane Bouacida, Thierry Roisnel, Chafia Bentchouala, Farida Smati, Bertrand Carboni, Ali Belfaitah.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 2 , 2013

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Some new unfused tricyclic aromatic systems containing various heterocyclic cores were synthesized. These compounds were prepared in good yields via appropriate routes using 6-methyl-2-phenylquinoline-3-carbaldehyde as a key intermediate. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Salmonella thipymurium using the disk-diffusion method. The minimum inhibitory concentration (MIC) was determined for the tested compounds.

Keywords: 2-Phenylquinoline, heterocycles, crystal structure, antimicrobial activity, minimum inhibitory concentration

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Article Details

Year: 2013
Page: [94 - 99]
Pages: 6
DOI: 10.2174/1570178611310020005
Price: $58

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