Some new unfused tricyclic aromatic systems containing various heterocyclic cores were synthesized. These
compounds were prepared in good yields via appropriate routes using 6-methyl-2-phenylquinoline-3-carbaldehyde as a
key intermediate. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus
aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Salmonella thipymurium using the disk-diffusion
method. The minimum inhibitory concentration (MIC) was determined for the tested compounds.
Keywords: 2-Phenylquinoline, heterocycles, crystal structure, antimicrobial activity, minimum inhibitory concentration
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