Title:Synthesis of <i>N,N’</i>-Diacetyl-β-Chitobiosyl <i>N</i>-Glycooxazoline
VOLUME: 10 ISSUE: 2
Author(s):Hualiang Huang, Shuangquan Shu, Feng Xiao and Gangliang Huang
Affiliation:College of Chemistry, Chongqing Normal University, Chongqing, 401331, P.R. China.
Keywords:N, N’-Diacetyl-β-chitobiosyl N-glycooxazoline, synthesis, glycosylation, catalytic hydrogenation, photolysis
Abstract:The synthesis of N,N’-diacetyl-β-chitobiosyl N-glycooxazoline 2 was investigated. A routine method was used
to prepare the N-benzyloxycarbonyl (Cbz) protected trichloroacetimidate donors 11 and 13. The synthesis was carried
through using polystyrene as solid-phase support and o-nitrobenzyl ether tether as linker. The target compound 2 was efficiently
obtained by iterative glycosylations, catalytic hydrogenation, acetylation, deacetylation, and photolysis.
