Synthesis of N,N’-Diacetyl-β-Chitobiosyl N-Glycooxazoline

Author(s): Hualiang Huang, Shuangquan Shu, Feng Xiao, Gangliang Huang.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 2 , 2013

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Abstract:

The synthesis of N,N’-diacetyl-β-chitobiosyl N-glycooxazoline 2 was investigated. A routine method was used to prepare the N-benzyloxycarbonyl (Cbz) protected trichloroacetimidate donors 11 and 13. The synthesis was carried through using polystyrene as solid-phase support and o-nitrobenzyl ether tether as linker. The target compound 2 was efficiently obtained by iterative glycosylations, catalytic hydrogenation, acetylation, deacetylation, and photolysis.

Keywords: N, N’-Diacetyl-β-chitobiosyl N-glycooxazoline, synthesis, glycosylation, catalytic hydrogenation, photolysis

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2013
Page: [91 - 93]
Pages: 3
DOI: 10.2174/1570178611310020004
Price: $58

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