Study on Synthesis of 2-(Substituted Benzylidene)amino-2-Deoxy-1,3,4,6- Tetra-O-Acetyl-β-D-Glucopyranoses from D-Glucosamine

Author(s): Nguyen Dinh Thanh, Nguyen Van Quoc.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 2 , 2013

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The conditions in catalysts and in reaction time for the reaction of protected α-D-glucosamine hydrochloride with different substituted benzaldehydes have been investigated in the presence of various inorganic and organic bases. Based on obtained results, the general procedure for the synthesis of Schiff’s bases from tetra-O-acetyl-β-D-glucosamine hydrochloride and substituted benzaldehydes has been optimized. Reaction yields were 28-80%. Azomethines 6a-i have the scavenging effect on the DPPH radical with values of IC50 of 50-75 μM.

Keywords: D-glucosamine, substituted benzaldehydes, schiff bases, tetra-O-acetyl-β-D-glucosamine hydrochloride, DPPH

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Article Details

Year: 2013
Page: [85 - 90]
Pages: 6
DOI: 10.2174/1570178611310020003
Price: $65

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