The conditions in catalysts and in reaction time for the reaction of protected α-D-glucosamine hydrochloride
with different substituted benzaldehydes have been investigated in the presence of various inorganic and organic bases.
Based on obtained results, the general procedure for the synthesis of Schiff’s bases from tetra-O-acetyl-β-D-glucosamine
hydrochloride and substituted benzaldehydes has been optimized. Reaction yields were 28-80%. Azomethines 6a-i have
the scavenging effect on the DPPH radical with values of IC50 of 50-75 μM.
Keywords: D-glucosamine, substituted benzaldehydes, schiff bases, tetra-O-acetyl-β-D-glucosamine hydrochloride, DPPH
Rights & PermissionsPrintExport