The 18 kDa translocator protein (TSPO) is able to modulate several mitochondria-related cell death processes
due to close association with proteins and other molecules involved to the mitochondrial permeability transition pore. In
this way, herein we review cell death mechanisms targeting mitochondria, including programmed cell death type I, II and
III. Several proteins involved in these cell death processes and with a possible interplay with the TSPO are also discussed
including the voltage dependent anion channel, the adenine nucleotide transporter, cardiolipin, and the Bcl-2 family proteins.
Noteworthy, TSPO has been also implicated in various other functions including mitochondrial respiration, immune
and phagocytic host-defense response, microglial activation, inflammation, cell growth and differentiation, cancer, cell
proliferation, ischemia, and mental and neuropathological disorders. We focused in recent studies of the TSPO particularly
on cancer and neurodegeneration, thus presenting the TSPO as a core element in the role of mitochondria in diseases
and related processes. Clinical benefit may be attainable by increasing pharmacological knowledge related to the TSPO.
Recent patents typically relate to diagnosis and treatment of TSPO-related pathological conditions including cancer, and
inflammatory conditions, as well as disorders associated with central nervous system, such as neurodegeneration, convulsions,
anxiety, mental disorders, and dementia.