Title:Large-Scale and Facile Synthesis of Biocompatible Yb-Based Nanoparticles as a Contrast Agent for In Vivo X-Ray Computed Tomography Imaging
VOLUME: 13 ISSUE: 4
Author(s):Jianhua Liu, Rui Xin, Zhiman Li, Reza Golamaully, Yan Zhang, Jishen Zhang, Qinghai Yuan and Xiaodong Liu
Affiliation:Department of Radiology, The Second Hospital of Jilin University, 218# Ziqiang Street, Nanguan District, Changchun, P. R. China, 130041.
Keywords:Yb-based nanoparticles, imaging agent, biocompatibility, large-scale synthesis, biomedicine.
Abstract:X-ray computed tomography (CT), an efficient non-invasive clinical technique, usually provides highresolution
3D structure details of tissues in early disease diagnosis. Here, we report a high-performance CT imaging platform
based on a monodispersed Yb-based nanoparticulate contrast agent. The well-prepared nanoprobes presented excellent
in vitro and in vivo performances in the CT imaging, very low cytotoxicity and no detectable tissue damage in one
month. More significantly, compared with routinely used Iobitridol in clinic, our Yb-based CT contrast agents provided
much more enhanced contrast at a clinical 120 kVp voltage. Additionally, these nanoparticulate contrast agent could be
excreted mainly via feces and urine, indicating the total elimination from the animal bodies and more potential for further
biomedical applications.
