Transient Receptor Potential Channels and Dermatological Disorders
Rodrigo Valdes-Rodriguez, Shivani B. Kaushik and Gil Yosipovitch
Affiliation: Department of Dermatology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
Keywords: TRPV, TRPA, TRPM, TRPC, TRPML, Itch, skin barrier, hair growth, skin cancers
Transient receptor potential (TRP) cation channels are an emerging field of research in dermatology. Beyond
their classical role in skin sensory perception, TRPs are involved in various cutaneous functions that include keratinocyte
differentiation, apoptosis and melanocyte pigmentation. In addition, they have a role as pharmacological targets in many
inflammatory skin diseases including psoriasis, chronic itch, hair disorders and skin cancers. Moreover, mutations in
TRPs have recently been related to rare skin conditions such as Olmsted syndrome. This review will cover the role of
TRPs in dermatologic conditions with special emphasis on itch and skin inflammatory diseases.
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