Targeting TRPs in Neurodegenerative Disorders

Author(s): Yoshinori Takada , Tomohiro Numata , Yasuo Mori .

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 3 , 2013

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Abstract:

Neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis present a significant medical challenge in the modern world. Recent evidence indicates that perturbation of neuronal Ca2+ homeostasis is involved in the pathogenesis of these neurodegenerative disorders. Transient receptor potential (TRP) channels are non-selective cation channels that are expressed in various cell types and tissues, and play an important role in regulating Ca2+ signaling in both non-neuronal and neuronal cells. TRP channels are related to the onset or progression of several diseases, and defects in the genes encoding TRP channels (so-called “TRP channelopathies”) underlie certain neurodegenerative disorders due to their abnormal Ca2+ signaling properties. In this article, we review recent findings regarding the relationship between TRPs and neurodegenerative disorders, and discuss the therapeutic potential of targeting TRP channels pharmacologically.

Keywords: TRP channels, neurodegenerative disorders, oxidative stress, Ca2+ homeostasis, neuronal cell death, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, epilepsy, ataxia, bipolar disorders, ischemia, stroke, muscle atrophy, channelopathy

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Article Details

VOLUME: 13
ISSUE: 3
Year: 2013
Page: [322 - 334]
Pages: 13
DOI: 10.2174/1568026611313030009
Price: $58

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