Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors

Author(s): C.N. Kapanda, J.H. Poupaert, D.M. Lambert.

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 14 , 2013

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Abstract:

Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.

Keywords: Endocannabinoid hydrolases, inhibitors, design, chemical structures, inhibition mechanism, structure-activity relationships.

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Article Details

VOLUME: 20
ISSUE: 14
Year: 2013
Page: [1824 - 1846]
Pages: 23
DOI: 10.2174/09298673113209990108
Price: $58

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