Advances in Organic Synthesis

Volume: 6

Indexed in: Scopus, EBSCO, Ulrich's Periodicals Directory

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. It presents comprehensive articles written by eminent authorities ...
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Advances in the Synthesis of Amino Acids and Analogues for Foldamers Study

Pp. 436-486 (51)

Debasish Haldar

Abstract

Synthetic amino acids have particular appeal to extend our understanding of protein structure and stabilization into the realm of folded, non biological polymers. Chemists are now beginning to design biomimetic amino acids that can form both secondary and tertiary structures. An overview of the synthesis of non-protein amino acids recently used in the design of conformationally well-defined foldamers—artificial oligomers that also adopt well-defined folded conformations— are discussed.

Keywords:

Nonproteinogenic amino acids, amino acids analogues, synthesis, foldamers, single helix, double helical structure, helicate, strand, extended helix, quadruple helix, α-amino acid, glyco α-amino acids, β-amino acids, β-Substituted β- amino acids, α-substituted β-amino acids, heterocyclic β-amino acid, γ- Aminobutyric acid, pyrrole amino acid, δ-amino acids, arginine analogues, Dioxabicyclo amino acids, fullerene substituted amino acid, ferrocene substituted amino acids.

Affiliation:

Department of Chemical Sciences, Indian Institute of Science Education and Research –Kolkata, Mohanpur, West Bengal- 741252, India.