Recent Patents on CNS Drug Discovery (Discontinued)

Vincenzo Di Marzo
Istituto di Chimica Biomolecolare (I.C.B.)
Consiglio Nazionale delle Ricerche (C.N.R.)
Via Campi Flegrei 34
Pozzuoli, Napoli 80078


Targets of Anti-glucocorticoid Therapy for Stress-related Diseases

Author(s): Antonio Martocchia, Manuela Stefanelli, Giulia M Falaschi, Lavinia Toussan, Massimiliano Rocchietti March, Silvia Raja, Gloria Romano, Paolo Falaschi.


The stress response during chronic conditions increases vulnerability to diseases through the activation of adaptive systems, in particular, the hypothalamus-pituitary-adrenal (HPA) axis. Dysregulation in HPA activity (central and peripheral) has been reported in chronic diseases, like metabolic syndrome, type-2 diabetes mellitus, atherosclerosis-related disease, essential hypertension, dementia, depression, particularly during comorbid conditions.

Different targets of anti-glucocorticoid treatment have been proposed, acting at supra-hypothalamic, HPA axis, glucocorticoid receptor and post-receptor levels. The recent promising patents on the therapy against glucocorticoid-mediated damage will be presented and discussed.

Keywords: Corticosteroid, HPA axis, glucocorticoid receptor, stress.

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Article Details

Year: 2013
Page: [79 - 87]
Pages: 9
DOI: 10.2174/1574889811308010007