Recent Patents on CNS Drug Discovery

Vincenzo Di Marzo
Istituto di Chimica Biomolecolare (I.C.B.)
Consiglio Nazionale delle Ricerche (C.N.R.)
Via Campi Flegrei 34
Pozzuoli, Napoli 80078
Italy

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Targets of Anti-glucocorticoid Therapy for Stress-related Diseases

Author(s): Antonio Martocchia, Manuela Stefanelli, Giulia M Falaschi, Lavinia Toussan, Massimiliano Rocchietti March, Silvia Raja, Gloria Romano and Paolo Falaschi

Affiliation: S. Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy.

Keywords: Corticosteroid, HPA axis, glucocorticoid receptor, stress.

Abstract:

The stress response during chronic conditions increases vulnerability to diseases through the activation of adaptive systems, in particular, the hypothalamus-pituitary-adrenal (HPA) axis. Dysregulation in HPA activity (central and peripheral) has been reported in chronic diseases, like metabolic syndrome, type-2 diabetes mellitus, atherosclerosis-related disease, essential hypertension, dementia, depression, particularly during comorbid conditions.

Different targets of anti-glucocorticoid treatment have been proposed, acting at supra-hypothalamic, HPA axis, glucocorticoid receptor and post-receptor levels. The recent promising patents on the therapy against glucocorticoid-mediated damage will be presented and discussed.

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Article Details

VOLUME: 8
ISSUE: 1
Page: [79 - 87]
Pages: 9
DOI: 10.2174/1574889811308010007