Targets of Anti-glucocorticoid Therapy for Stress-related Diseases

Author(s): Antonio Martocchia, Manuela Stefanelli, Giulia M Falaschi, Lavinia Toussan, Massimiliano Rocchietti March, Silvia Raja, Gloria Romano, Paolo Falaschi.

Journal Name: Recent Patents on CNS Drug Discovery (Discontinued)

Volume 8 , Issue 1 , 2013

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Abstract:

The stress response during chronic conditions increases vulnerability to diseases through the activation of adaptive systems, in particular, the hypothalamus-pituitary-adrenal (HPA) axis. Dysregulation in HPA activity (central and peripheral) has been reported in chronic diseases, like metabolic syndrome, type-2 diabetes mellitus, atherosclerosis-related disease, essential hypertension, dementia, depression, particularly during comorbid conditions.

Different targets of anti-glucocorticoid treatment have been proposed, acting at supra-hypothalamic, HPA axis, glucocorticoid receptor and post-receptor levels. The recent promising patents on the therapy against glucocorticoid-mediated damage will be presented and discussed.

Keywords: Corticosteroid, HPA axis, glucocorticoid receptor, stress.

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2013
Page: [79 - 87]
Pages: 9
DOI: 10.2174/1574889811308010007

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