Copper-Catalyzed Synthesis of Isoquinolines by the Cyclocondensation of ortho- Alkynyl Aromatic Aldehydes or Ketones with Urea

Author(s): Jia Ju, Ruimao Hua.

Journal Name: Current Organic Synthesis

Volume 10 , Issue 2 , 2013

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Abstract:

A simple and efficient synthesis of isoquinoline derivatives by the condensation of ortho-alkynyl aromatic aldehydes/ketones with urea in the presence of copper salts is developed.

Keywords: o-Alkynyl aromatic aldehyde, o-Alkynyl aromatic ketone, cyclocondensation, isoquinoline derivative, urea

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2013
Page: [328 - 332]
Pages: 5
DOI: 10.2174/1570179411310020007
Price: $58

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