Diabetes and chronic heart failure are interrelated conditions with major medical and economic impact that
have to be treated as a distinct entity. Several pathological mechanisms have been investigated and proposed to explain
the structural and functional changes associated with diabetic cardiomyopathy. These mechanisms are likely to act
synergically and may potentiate one the other. This review outlines recent advances in the pathophysiological mechanisms
implicated in the development and progression of diabetic cardiomyopathy and in current therapeutic strategies.
Keywords: Chronic heart failure, diabetes mellitus, diabetic cardiomyopathy, molecular mechanisms, structural alteration,
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