Biotransformation of Vulgarin

Author(s): Khaled Y. Orabi, Farouk S. El-Feraly, Waleed A. Al-Sulmy, Mohammed A. Al-Yahya.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 5 , 2013

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Abstract:

Using a standard two-stage fermentation technique, the fungus Beauveria bassiana (ATCC 7159) was found to convert the eudesmanolide vulgarin (1) to 1α,4α-dihydroxy-5αH,6,11βH-eudesman-6,12-olide (2). The use of the yeast Hansenula anomala ATCC 20170 instead, produced the less polar 4α-hydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide (3), in addition to the more polar 3α,4α-dihydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide (4). These metabolites were characterized on the basis of their spectral data and the identity of 4 was further confirmed by chemical synthesis.

Keywords: Vulgarin, Biotransformation, 1-epi-tetrahydrovulgarin, dihydrovulgarin, 3α-hydroxydihydrovulgarin

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2013
Page: [777 - 782]
Pages: 6
DOI: 10.2174/1389557511313050013
Price: $58

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