Quinolines as Chemotherapeutic Agents for Leishmaniasis

Author(s): Kristie A. Reynolds , Wendy A. Loughlin , David J. Young .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 5 , 2013

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Abstract:

The development of leishmanicidal quinolines and their in vitro (promastigote and amastigote) and, where applicable, in vivo activities are reviewed. This survey provides a direct comparison of bioactivity across different species (e.g. L. donovani, L. amazonensis, L. chagasi, L infantum), and in different animal models (e.g. L. donovani Balb/c mice and L. donovani infected hamsters). The progress of selected quinolines through pre-clinical development and phase I/II trials, and the lead quinoline drugs sitamaquinine and Imiquimod, are discussed in conjunction with delivery systems and combination therapies.

Keywords: Leishmaniasis, quinolines, affordable chemotherapies

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2013
Page: [730 - 743]
Pages: 14
DOI: 10.2174/1389557511313050010
Price: $58

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