A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists

Author(s): Pooja S. Banerjee, Subir Samanta.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 5 , 2013

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Abstract:

Peroxisome Proliferator Activated Receptors gamma (PPARγ) are a class of ligand activated transcription factors with a prominent role in the regulation of metabolic processes. The present work aims towards examining the functional and structural features that facilitate the binding of small molecules based on Thiazolidinedione pharmacophore to PPARs. The intent of this article is to review all the reported thiazolidinediones and associated groups of PPARγ ligands.

Keywords: Natural ligands, Pharmacophore, PPARγ, Synthetic ligands, Thiazolidinediones, Type II Diabetes

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2013
Page: [706 - 712]
Pages: 7
DOI: 10.2174/1389557511313050007
Price: $58

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