Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Design, Synthesis and Anticancer Activity Evaluation of Diazepinomicin Derivatives

Author(s): Yongguo Yu, Jianbo Wu, Fan Lei, Lei Chen, Weili Wan, Li Hai, Mei Guan, Yong Wu.

Abstract:

A series of diazepinomicin derivatives were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds. Based on the results, preliminary structure-activity relationships were discussed.

Keywords: Diazepinomicin, Derivatives, Synthesis, Anticancer

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2013
Page: [369 - 373]
Pages: 5
DOI: 10.2174/1570180811310040011
Price: $58