Synthesis and Characterization of Clubbed Thiazolidin-4-one, Quinoline and Barbitone Derivatives as a Potent Antimicrobial Agents

Title:Synthesis and Characterization of Clubbed Thiazolidin-4-one, Quinoline and Barbitone Derivatives as a Potent Antimicrobial Agents

Volume: 10 Issue: 4

Author(s): Nisheeth Chhotalal Desai, Hitesh Mansukhbhai Satodiya, Kiran Mavjibhai Rajpara, Vivek Vishnuprasad Joshi and Hasit Vinodray Vaghani

Affiliation:

Keywords: Barbitone, Quinoline, Thiazolidin-4-one

Abstract: In the present investigation, it was of interest to synthesized some new derivatives of pyrimidine- 2,4,6(1H,3H,5H)-trione moiety incorporated with different biologically active pharmacophores such as thiazolidin-4- one, barbitone and 2-chloroquinoline-3-carbaldehyde. The structures of synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, and mass spectral data. Antimicrobial screening of title compounds were examined against Grampositive bacteria (Staphylococcus aureus and Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and three fungal species (Candida albicans, Aspergillus niger, and Aspergillus clavatus) by serial broth dilution method. Compounds 6b, 6e, 6f and 6h were associated with considerably higher antibacterial and antifungal activities.

Cite this article as:

Chhotalal Desai Nisheeth, Mansukhbhai Satodiya Hitesh, Mavjibhai Rajpara Kiran, Vishnuprasad Joshi Vivek and Vinodray Vaghani Hasit, Synthesis and Characterization of Clubbed Thiazolidin-4-one, Quinoline and Barbitone Derivatives as a Potent Antimicrobial Agents, Letters in Drug Design & Discovery 2013; 10 (4) . https://dx.doi.org/10.2174/1570180811310040007