Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Targeting the mTOR Pathway in Tumor Malignancy

Author(s): Hengmiao Cheng, Marlena Walls, Sangita M. Baxi, Min-Jean Yin.

Abstract:

The mammalian target of rapamycin (mTOR) plays a critical role in the regulation of cell growth, proliferation, and metabolism by integrating growth factor stimulation and energy/nutrient input through a complex signaling network. The mTOR kinase is a part of two structurally and functionally distinct multiple protein complexes, mTORC1 and mTORC2. The mammalian target of rapamycin complex 1 (mTORC1) is rapamycin-sensitive and mediates temporal control of cell growth by regulating several cellular processes, such as translation, transcription, and nutrient transport while the mammalian target of rapamycin complex 2 (mTORC2) is insensitive to rapamycin and is involved in spatial control of cell growth via cytoskeleton regulation. Here we discuss the mechanism of mTOR regulation in tumor malignancy through a variety of signaling pathways and the potential of mTOR inhibitors for the treatment of cancer.

Keywords: AKT, cancer therapeutics, mTOR, PI3K

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Article Details

VOLUME: 13
ISSUE: 3
Year: 2013
Page: [267 - 277]
Pages: 11
DOI: 10.2174/1568009611313030005
Price: $58