The PI3 Kinase Signaling Pathway in Prostate Cancer
Aymen A. Elfiky,
Despite recent advances in our understanding of the biological basis of prostate cancer, the management
of the disease, especially in the castration-resistant phase, remains a significant challenge. Deregulation of the
phosphatidylinositol 3-kinase (PI3K) pathway is increasingly implicated in a number of malignancies, including prostate
carcinogenesis. In this review, we detail the role of this pathway in the pathogenesis of prostate cancer and the therapeutic
implications of targeting it.
Keywords: Androgen receptor, mammalian target of rapamycin, phosphatidylinositol 3-kinase, prostate cancer, PTEN.
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