Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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The PI3 Kinase Signaling Pathway in Prostate Cancer

Author(s): Aymen A. Elfiky, Zhenyang Jiang.

Abstract:

Despite recent advances in our understanding of the biological basis of prostate cancer, the management of the disease, especially in the castration-resistant phase, remains a significant challenge. Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway is increasingly implicated in a number of malignancies, including prostate carcinogenesis. In this review, we detail the role of this pathway in the pathogenesis of prostate cancer and the therapeutic implications of targeting it.

Keywords: Androgen receptor, mammalian target of rapamycin, phosphatidylinositol 3-kinase, prostate cancer, PTEN.

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Article Details

VOLUME: 13
ISSUE: 2
Year: 2013
Page: [157 - 164]
Pages: 8
DOI: 10.2174/1568009611313020005
Price: $58