Abstract
Marine ecosystems constitute a huge reservoir of biologically active secondary metabolites. Consequently during the last past few decades, several marine-derived molecules have been approved for anticancer treatment or are under clinical trials. This review reports the present state of the art of the sixteen molecules approved or currently on the clinical pipeline for anticancer chemotherapy. The molecules are classified according to their current status in the phase (approved / phase IV / phase III / phase II / phase I) and data are updated to April 2012.
Keywords: Brentuximab vedotin, Clinical trials, Cytarabine, Elisidepsin, Eribulin, ILX-651, KLH, Marine natural products, MMAE, MMAF, Plinabulin, plitidepsin, PM00104, PM01183, PM060184, Salinosporamide A, Trabectedin, TZT-1027
Anti-Cancer Agents in Medicinal Chemistry
Title:Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status
Volume: 13 Issue: 4
Author(s): Karina Petit and Jean-Francois Biard
Affiliation:
Keywords: Brentuximab vedotin, Clinical trials, Cytarabine, Elisidepsin, Eribulin, ILX-651, KLH, Marine natural products, MMAE, MMAF, Plinabulin, plitidepsin, PM00104, PM01183, PM060184, Salinosporamide A, Trabectedin, TZT-1027
Abstract: Marine ecosystems constitute a huge reservoir of biologically active secondary metabolites. Consequently during the last past few decades, several marine-derived molecules have been approved for anticancer treatment or are under clinical trials. This review reports the present state of the art of the sixteen molecules approved or currently on the clinical pipeline for anticancer chemotherapy. The molecules are classified according to their current status in the phase (approved / phase IV / phase III / phase II / phase I) and data are updated to April 2012.
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Cite this article as:
Petit Karina and Biard Jean-Francois, Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (4) . https://dx.doi.org/10.2174/1871520611313040010
DOI https://dx.doi.org/10.2174/1871520611313040010 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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