Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status
Marine ecosystems constitute a huge reservoir of biologically active secondary metabolites. Consequently during the last past
few decades, several marine-derived molecules have been approved for anticancer treatment or are under clinical trials. This review
reports the present state of the art of the sixteen molecules approved or currently on the clinical pipeline for anticancer chemotherapy.
The molecules are classified according to their current status in the phase (approved / phase IV / phase III / phase II / phase I) and data
are updated to April 2012.
Keywords: Brentuximab vedotin, Clinical trials, Cytarabine, Elisidepsin, Eribulin, ILX-651, KLH, Marine natural products, MMAE,
MMAF, Plinabulin, plitidepsin, PM00104, PM01183, PM060184, Salinosporamide A, Trabectedin, TZT-1027
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