Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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FAK and Nanog Cross Talk with p53 in Cancer Stem Cells

Author(s): Vita M. Golubovskaya.

Abstract:

This review is focused on the role of Focal Adhesion Kinase (FAK) signaling in cancer stem cells. The recent data demonstrate the important role of FAK in cancer stem cell proliferation, differentiation, motility, and invasion. We showed recently that the transcription factor Nanog binds the FAK promoter and up-regulates FAK expression, and that FAK binds Nanog and phosphorylates it. This review discusses the interaction of FAK, Nanog, Oct-3/4, and Sox-2 signaling pathways that are critical for the regulation of cancer stem cells. The cross-linked signaling of FAK with p53 and Nanog signaling in cancer stem cell and function and targeted therapeutics approaches are discussed.

Keywords: Adhesion, Cancer, Focal Adhesion Kinase, Inhibitor, Metastasis, Tumor

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2013
Page: [576 - 580]
Pages: 5
DOI: 10.2174/1871520611313040006
Price: $58