Cell Survival Signaling in Neuroblastoma

Author(s): Michael L. Megison , Lauren A. Gillory , Elizabeth A. Beierle .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 13 , Issue 4 , 2013

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Abstract:

Neuroblastoma is the most common extracranial solid tumor of childhood and is responsible for over 15% of pediatric cancer deaths. Neuroblastoma tumorigenesis and malignant transformation is driven by overexpression and dominance of cell survival pathways and a lack of normal cellular senescence or apoptosis. Therefore, manipulation of cell survival pathways may decrease the malignant potential of these tumors and provide avenues for the development of novel therapeutics. This review focuses on several facets of cell survival pathways including protein kinases (PI3K, AKT, ALK, and FAK), transcription factors (NF-κB, MYCN and p53), and growth factors (IGF, EGF, PDGF, and VEGF). Modulation of each of these factors decreases the growth or otherwise hinders the malignant potential of neuroblastoma, and many therapeutics targeting these pathways are already in the clinical trial phase of development. Continued research and discovery of effective modulators of these pathways will revolutionize the treatment of neuroblastoma.

Keywords: Cell Survival, Neuroblastoma, Kinases, Phosphorylate, Transcription Factors

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2013
Page: [563 - 575]
Pages: 13
DOI: 10.2174/1871520611313040005
Price: $58

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