Title:Investigation of Anticholinesterase Activity of a Series of Salvia Extracts and the Constituents of Salvia staminea
VOLUME: 3 ISSUE: 1
Author(s):Gulactı Topcu, Ufuk Kolak, Mehmet Ozturk, Mehmet Boga, Seda Damla Hatipoglu, Fatemeh Bahadori, Burcu Culhaoglu and Tuncay Dirmenci
Affiliation:Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, 34093, Turkey.
Keywords:Anticholinesterase, antioxidant, ferruginol, Salvia species, S. staminea, taxodione
Abstract:In continuation of our studies on the genus Salvia fourteen alcoholic extracts of Salvia species were evaluated
for their anticholinesterase activity. Among them, the most active extract at 200 μg/mL was found to be S. staminea with
the inhibition of 55.17 and 79.75% against enzymes AChE and BChE, respectively. Pure isolated compounds from S.
staminea were investigated for anticholinesterase activity at 200 μM, and the abietane diterpenoids ferruginol and
taxodione were found to be the most promising isolates, which were then further investigated at five different
concentrations, and both diterpenoids exhibited high activity, particularly against BChE enzyme with IC50 values of 7.73
and 10.52 μM, respectively. Salvia chrysophylla and Salvia poculata extracts also exhibited moderate anticholinesterase
activity.
