Abstract
In continuation of our studies on the genus Salvia fourteen alcoholic extracts of Salvia species were evaluated for their anticholinesterase activity. Among them, the most active extract at 200 μg/mL was found to be S. staminea with the inhibition of 55.17 and 79.75% against enzymes AChE and BChE, respectively. Pure isolated compounds from S. staminea were investigated for anticholinesterase activity at 200 μM, and the abietane diterpenoids ferruginol and taxodione were found to be the most promising isolates, which were then further investigated at five different concentrations, and both diterpenoids exhibited high activity, particularly against BChE enzyme with IC50 values of 7.73 and 10.52 μM, respectively. Salvia chrysophylla and Salvia poculata extracts also exhibited moderate anticholinesterase activity.
Keywords: Anticholinesterase, antioxidant, ferruginol, Salvia species, S. staminea, taxodione
The Natural Products Journal
Title:Investigation of Anticholinesterase Activity of a Series of Salvia Extracts and the Constituents of Salvia staminea
Volume: 3 Issue: 1
Author(s): Gulactı Topcu, Ufuk Kolak, Mehmet Ozturk, Mehmet Boga, Seda Damla Hatipoglu, Fatemeh Bahadori, Burcu Culhaoglu and Tuncay Dirmenci
Affiliation:
Keywords: Anticholinesterase, antioxidant, ferruginol, Salvia species, S. staminea, taxodione
Abstract: In continuation of our studies on the genus Salvia fourteen alcoholic extracts of Salvia species were evaluated for their anticholinesterase activity. Among them, the most active extract at 200 μg/mL was found to be S. staminea with the inhibition of 55.17 and 79.75% against enzymes AChE and BChE, respectively. Pure isolated compounds from S. staminea were investigated for anticholinesterase activity at 200 μM, and the abietane diterpenoids ferruginol and taxodione were found to be the most promising isolates, which were then further investigated at five different concentrations, and both diterpenoids exhibited high activity, particularly against BChE enzyme with IC50 values of 7.73 and 10.52 μM, respectively. Salvia chrysophylla and Salvia poculata extracts also exhibited moderate anticholinesterase activity.
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Topcu Gulactı, Kolak Ufuk, Ozturk Mehmet, Boga Mehmet, Damla Hatipoglu Seda, Bahadori Fatemeh, Culhaoglu Burcu and Dirmenci Tuncay, Investigation of Anticholinesterase Activity of a Series of Salvia Extracts and the Constituents of Salvia staminea, The Natural Products Journal 2013; 3 (1) . https://dx.doi.org/10.2174/2210315511303010003
DOI https://dx.doi.org/10.2174/2210315511303010003 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
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