DNAJ Proteins and Protein Aggregation Diseases

Author(s): Vaishali Kakkar, Louis C. B. Prins, Harm H. Kampinga.

Journal Name: Current Topics in Medicinal Chemistry

Volume 12 , Issue 22 , 2012

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Abstract:

Many neurodegenerative diseases are late onset diseases, associated with aggregation of proteins, implying that aged cells are more susceptible to proteotoxic stress. It is known that with aging, there is a decline in the functionality of chaperone networks and on the other hand, accumulation of damaged proteins occurs. Together, this has a cumulative effects on cellular protein homeostasis. Several studies have revealed that availability of DNAJ proteins, the cochaperones to the Hsp70 machine, could be a rate-limiting factor in handling diseased proteins within the cell. In this review, we highlight how DNAJ proteins can affect aggregation of disease-causing proteins, if and how this depends on their function as Hsp70 co-chaperones, and how much this depends on the type of protein causing the disease. Finally, we will discuss the five known degenerative diseases that are linked to mutations in individual DNAJ members and what mechanism may underlie these DNAJ chaperonopathies.

Keywords: Protein aggregation diseases, DNAJ proteins, neurodegeneration, Hsp70, chaperonopathies, protein quality control

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Article Details

VOLUME: 12
ISSUE: 22
Year: 2012
Page: [2479 - 2490]
Pages: 12
DOI: 10.2174/1568026611212220004
Price: $58

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