Neuropsychiatric disorders are devastating mental illnesses with a high economic burden. The additional
morbidity associated with social issues that arises along with the course of these diseases increases the need for a clear
understanding of their etiopathogenesis to allow an implementation of novel pharmacological strategies. Yet a poor
knowledge about interactions occurring at the glia-neuron interface in health and disease still hampers innovative
discoveries, despite the fact that glia cells have been long described to actively participate in the regulation of brain circuits.
The purpose of this review was to collect the scattered literature on the involvement of glia cells in neuropsychiatric
disorders and to describe how also these cells besides neurons might be responsive to current pharmacological
interventions. We hope thereby to offer alternative approaches for investigations that may open avenues to search for new
potential targets for drug discovery.
Keywords: Astrocytes, microglia, neuropsychiatric disorders, oligodendrocytes, pharmacotherapy
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