Nanoformulated Antibiotics: the Next Step for Pathogenic Bacteria Control

Author(s): Amanda Caroline Marques Saude, Mariana Dornelles Cherobim, Andre Correa Amaral, Simoni Campos Dias, Octavio Luiz Franco.

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 10 , 2013

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Abstract:

The resistance of infectious bacteria to current antibiotics is a worldwide problem. Previous studies have demonstrated the efficacy of nanostructured molecules against pathogens as an innovative methodology for the development of novel drugs. Currently, 95% of properties limited pharmacies applicability such as low solubility, short half-life in the circulatory system, toxicity associated to controlled release and immunogenicity. Furthermore, nanobiotechnology provides a different perspective for modifying these properties and allows innovative drug development. In this context, this review aims to describe different methods, polymers, and drugs used to obtain and analyze nanostructures associated with antibiotics as an unconventional and innovative tool for bacterial control. Biotechnology provides a different perspective for modifying drug properties and allows innovative drug development. This review describes nanostructures in association with antibiotics as an unconventional and innovative tool for bacterial control.

Keywords: Antibiotics, bacteria, nanoparticles, antimicrobial peptides, infectious diseases

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Article Details

VOLUME: 20
ISSUE: 10
Year: 2013
Page: [1232 - 1240]
Pages: 9
DOI: 10.2174/0929867311320100004
Price: $58

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